Current methodologies utilized in the conduct of randomized clinical trials

Clinical trials registries are under-utilized in the conduct of systematic reviews: a cross-sectional analysis

BACKGROUND Publication bias is a major threat to the validity of systematic reviews. Searches of clinical trials registries can help to identify unpublished trials, though little is known about how often these resources are utilized. We assessed the usage and results of registry searches reported in systematic reviews published in major general medical journals. METHODS This cross-sectional a...

unethical conduct of underpowered clinical trials

letter to the editor

Management and Conduct of Randomized Controlled Trials Knatterud Management and Conduct of Randomized Controlled Trials

“A properly planned and executed clinical trial is a powerful experimental technique for assessing the effectiveness of an intervention” (1, p. 2). This paper will discuss the issues related to the proper planning and execution of a multicenter clinical trial. The importance of a detailed protocol and manual of operations should not be underestimated. The fundamental principles are relatively s...

Clinical Trials Registry--India: redefining the conduct of clinical trials.

Unethical Conduct of Underpowered Clinical Trials

I read with interest the article on the effect of antiseptics on the colonization rate of central venous catheters, published in the recent issue of your Journal.1 Although the topic is very important, the study suffers from many shortcomings, the most important of which is low study power. Assuming expected prevalence rates of 22% and 17% in the control and treatment groups (an effect size of ...